Lack of Significant Effects of Chlamydia trachomatis Infection on Cervical Adenocarcinoma Risk: Nested Case-Control Study.

Lack of Significant Effects of Chlamydia trachomatis Infection on Cervical Adenocarcinoma Risk: Nested Case-Control Study.

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BackgroundA role of Chlamydia trachomatis in HPV-induced cervical carcinogenesis has been reported for cervical cancer but studies on cervical adenocarcinoma are limited.MethodsA total of 1,553 cervical smears taken up to 26 years before diagnosis in a large population-based nested case-control study of cervical adenocarcinoma (AC, 132 cases with matched echofix spring reverb controls), and adenocarcinoma in situ (AIS, 159 cases with matched controls) were tested for C.trachomatis and HPV DNA by a type-specific PCR bead-based multiplex genotyping (TS-MPG) assay.ResultsOnly 1.7% of samples were positive for C.

trachomatis, with no significant differences between AC/AIS cases and controls.HPV-positivity was detected in 49.3% of C.trachomatis-negative and 2014 dodge ram 1500 fender flares 65.4% C.

trachomatis-positive samples, respectively.ConclusionsA large prospective study did not find any risk for cervical adenocarcinoma and/or AIS conferred by C.trachomatis infection.ImpactC.trachomatis appears not to be involved in cervical adenocarcinomas.